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PHARMACOLOGY: Pharmacodynamics: Clotrimazole exerts its antifungal activity by altering cell membrane permeability, apparently by binding with phospholipids in the fungal cell membrane. As a result of alteration of permeability, the cell membrane is unable to function as a selective barrier, and potassium and other cellular constituents are lost.
Pharmacokinetics: Small amounts of Clotrimazole are absorbed systemically when the drug is administered intravaginally. About 3-10% of an intravaginal dose of the drug reaches systemic circulation, principally as metabolites.
